Astragalus membranaceus chu a awm a, Leguminosae chhungkaw zinga kum tin thing chi khat chuan a zung hring chu damdawi atan a hmang thin. Traditional Chinese medicine (TCM)-ah chuan a hnathawh ber chu "Qi tonifying leh exterior consolidating" a ni a, Qi tlakchhamna, hahna, mahni insiamthat, zan lama thawk hah, leh pawn lam natna hrik laka hlauhawmna ang chi symptoms atan hman a ni tlangpui. A concept tih chu"Qi" tiin.in TCM chu abstract functional notion a ni a, a connotation thenkhat chu tunlai damdawiin a sawi nen hian a inzawm tlat a ni"immunity" tih a ni. Astragalus polysaccharides hmanga siam a ni-Astragalus-a bioactive constituent hmasa ber-te hian TCM ngaihdan "Qi tonification" chu tunlai concept, immune support ang chi-a lehlinna tur scientific basis an pe a, hei hi immunomodulatory, antioxidant, leh anti-fatigue activity chak tak an neih vang a ni
Kum 2023 khan National Health Commission of China chuan Announcement No. 9 a tichhuak a, Astragalus, Codonopsis leh thil dang pasarih te chu ei leh in leh damdawi atana hman thin thil list-a telh thar turin a pawm a, chu chuan an hman theihna tur a tizau a ni.
(Thlalak lakna: National Health Commission of the People’s Republic of China atanga lak a ni)
Astragalus polysaccharides (APS) hi Astragalus-a core active component ni mahse, mihring intestine-ah hian chutiang complex polysaccharides direct-a hydrolyze theihna tura digestive enzymes mamawh chu a tlachham a ni. Extraction method pangngai hmanga macromolecular APS hmuhchhuah te hian intestinal epithelium chu awlsam takin a paltlang thei lo a, hei hian absorption efficiency a ti hniam hle a ni. Fraction tlemte chauh hi systemic circulation-ah an lut a, hei hi an bioavailability tlem chhan ber a ni.
Breakthrough - Chinese damdawi hmanlai te Fermentation
Direct absorption an neih tlem avangin Astragalus polysaccharides te hi a tam zawk chu intestinal tract chhungah an awm reng a ni. Tuna mainstream theory-te chuan APS hi special type of ang deuhin an che zawk niin an sawiprebiotic a ni. An nghawng chu a rinchhan loa hip lut ta a ni, mahse a kal zel zawkfermented a nih lai. Gut commensal microbes tana substrate anga thawk APS hi bacteria population \\angkai tak takte chuan an metabolize a, chu chuan an bioavailability a ti sang a ni
Chinese damdawi hmanrua microbial fermentation hian "traditional wisdom crystallization" a entir a ni. Historical processing methods chuan natural microorganisms te chu herbs nena inzawm tlat te hmangin "toxicity tihtlem, efficacy tihpun, leh damdawi property tihdanglam" tih tumna a thlen a ni. A bulpui berah chuan he kalphung hian...microbial metabolism leh herbal constituents te inkara thawhhona (synergistic interplay) a ni. Traditional physical processing (eg, roasting, calcining) emaw chemical processing (eg, vinegar-frying, wine-frying) ang lo takin microbial fermentation hian hlawkna lian tak pathum a nei a:mild reaction condition, directionality chak tak, leh product chi hrang hrang sang tak a awm bawk.
Microbial Fermentation hian Absorption aiin a tichak zawk daih
Fermentation process hian a sophisticated form angin hna a thawk apre-digestion tih a ni. Probiotic strain bikte chuan enzyme an tichhuak a, chu chuan -molecular-weight sang tak APS chu chiang takin a "cleave" a, low-molecular-weight polysaccharide fragment series-ah a siam a ni. He inthlak danglamna hlawkna nghal ber chu aabsorption-ah nasa takin a pung, active components te chu systemic circulation ah a luh theih nan a pui a ni.
Mahse, fermentation hlawkna chu uptake tihchangtlun aiin a hla hle. Zirna hrang hrangah chuan heng microbial fermentation hmanga siam chhuah heng low-molecular-weight fragments te hi a takah chuan the...immunostimulatory signal pawimawh tak tak te. Native macromolecular APS nena khaikhin chuan fragment te zawkte hian immune-recognition site tha zawk leh bioactivity tihchakna an nei a ni. Macrophages, T lymphocytes leh pivotal immune cell dangte hnathawh dan chu chiang zawkin an modulate a, chu chuan immune homeostasis tihregulate leh host defense capacity tihchakna kawngah nghawng ropui tak a nei tih an lantir a ni
Zirna tam tak chuan chutiang chu a tarlang fo thinlow-molecular-weight polysaccharides hian a tlangpuiin immunological activity chak zawk an lantir thin. Entir nan:
Low-molecular-weight ginseng polysaccharides (10.2 kDa) te hian an high-molecular-weight counterparts (21.3 kDa) te nena khaikhin chuan macrophage activation tha zawk an nei a ni
Low-molecular-weight glycyrrhiza polysaccharides (GP) hian intestinal immune regulation a nghawng tha hle[5];
Mushroom atanga immunologically active polysaccharides dangte, .Pueraria lobata tih hi a ni, leh a ang chi source-te pawhin molecular-weight range bik chhungah activity tha ber an lantir bawk[6].
A pum puia thlir chuan heng thil hmuhchhuah te hian...molecular-weight tihhniamna hmunpui berpolysaccharides te immunomodulatory efficacy tihpunna kawngah a ni.
